CRISPRclean Human rRNA Depletion Kit

RNA samples frequently contain up to 90% ribosomal RNA. Transcriptome sequencing without removing these noisy rRNA sequences reduces sequencing capacity and makes it harder to detect lower expressing, biologically relevant transcripts.

CRISPRclean Human rRNA Depletion Kit

Designed for Illumina NGS libraries, the CRISPRclean Human rRNA Depletion Kits remove overabundant human rRNA from sequencing workflows to improve sensitivity and performance.


  • Achieve 99% depletion rate of human rRNA.

  • Access low total RNA inputs below 1 ng - not possible with pre-library depletion methods. Tested down to 100 pg of Total RNA (10 cells).

  • Save time and streamline your workflow by pooling multiple samples in a single depletion reaction post-library preparation.

Species Human
Designed to deplete 5S, 5.8S, 18S, 28S, 45S (precursor), mito 12S, and 16S rRNA
Recommended library prep NEB Next Ultra II Directional RNA Library Prep for Illumina
Laura Steinke img

"Using Jumpcode’s accurate, efficient depletion techniques together with high-throughput sequencing has been a real turning point for my research. We can now generate data from enough low amount of samples to have real statistical significance.”

Laurey Steinke, PhD

 Associate Professor, Nebraska Medical Center

Product ordering

Each CRISPRclean Human rRNA Depletion Kit contains enough material for up to 3 reactions, and each reaction can contain up to 96 multiplexed samples.

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