CRISPRclean RNA Depletion Panel (Globin)

Focused RNA depletion panel for increasing detection sensitivity of low expressing transcripts in blood derived samples

CRISPRclean globin RNA depletion panel removes four highly expressed globin transcripts in-vitro ahead of sequencing, redistributing sequencing clusters to unique biologically relevant transcripts —allowing you to maximize UMI and gene sensitivity.

Beyond ribodepletion, RNA samples typically have a small number of highly expressed, well characterized transcripts, and resequencing these transcripts adds little biologically relevant information. Unfortunately, these highly expressed transcripts outcompete low expressing transcripts for sequencing coverage. This lack of sequencing coverage coupled with significant noise from high expressing transcripts limits detection of low expressing genes, rare variants and unique fusion events that may be disease drivers.

Highlights

  • Globin panel designed to deplete overexpressing transcripts in blood derived samples
  • Re-assign sequencing reads to lower expressing transcripts for increased coverage​
  • Maximize variant and isoform detection with less sequencing

About

Specification
Catalog KIT1024
Samples per kit 24
Tissues evaluated in design Blood
Designed to deplete 4 globin genes
CRISPRclean product compatibility Single cell (KIT1018) and ribodepletion (KIT1014)

CRISPRclean RNA Depletion Panel (Globin)

24 samples

$1,200.00 Add to Cart

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For the US patent, the patent number is US 10,604,802 entitled Genome Fractioning. The patent publication is available here.

For the EP patent, the patent number is EP3102722 entitled Genome Fractioning. The patent publication is available here.